Feb 22
Ordered arrays could significantly increase sequencing throughput
In Sequence has a post on a new ordered array technology developed by Xiaohua Huang’s group at The University of California, San Diego.
The ordered array approach uses a magnet to direct the assembly of DNA particles into a grid-like pattern on a microfluidic chip and offers a promising alternative for a number of high-throughput sequencing platforms that currently use random arrays of DNA molecules.
Ordered arrays could alleviate the problems faced by random arrays, such as low density and low imaging efficiency, and a demand for complex image analysis to recognize the shape, location, and intensity of signals on the chip. Since imaging is a severe bottleneck in most next generation sequencing technologies improvements in this area could dramatically increase throughput.
February 22nd, 2008 at 9:35 pm
[…] Wolf Tracking wrote an interesting post today onHere’s a quick excerptOrdered arrays could significantly increase sequencing throughput Tag: Research, Technology — rforsberg @ 9:17 pm In Sequence has a post on a new ordered array technology developed by Xiaohua Huang’s group at The University of California, San Diego. The ordered array approach uses a magnet to direct the assembly of DNA particles into a grid-like pattern on a microfluidic chip and offers a promising alternative for a number of high-throughput sequencing platforms that currently use random arr […]