CLC bio strive to support and take an active part in research projects. Here is a list of projects related to Next Generation Sequencing.
Sequencing of 100 Arab Human Genomes
An international consortium consisting of Saudi Biosciences, Beijing Genomics Institute Shenzhen, and CLC bio have in a joint effort performed an initial sequencing and analysis of the first Arab human genome, as part of a large project to sequence 100 Arab human genomes to map the unique genetic variations of the Arab population.
SEQNET
CLC bio and several prominent Danish research institutions have established SEQNET - a national network for developing a unique software platform for the analysis of data from the next generation sequencing technologies.
FøSu: Developing the Potato Plant into a Super-crop
CLC bio, several prominent Danish research institutions, and three crop-enhancing companies have joined forces in a project which aims to develop potatoes into a high-efficient, low-maintenance and multipurpose crop, which cannot only be used for animal and human food, but also for energy and chemical production, like biofuel and starch. The project will make extensive use of Next Generation Sequencing technology and Digital Gene Expression - also known as Tag-based Transcriptomics - to generate the knowledge for developing next generation crops.
Beijing Genomics Institute and CLC bio challenge vast volumes of bioinformatics data
A global leader within bioinformatics and genomics, Beijing Genomics Institute, has joined forces with the world’s leading bioinformatics solution provider, CLC bio, and genomics solutions experts, SD Genomics, to resolve one of the major barriers within the life science community today: To compute and understand the massive amounts of data created in academic research institutions as well as biotech and pharmaceutical companies.
High-Throughput Sequencing Technology Vendors
Many companies are involved in developing sequencing technologies. A few has been shipping instruments for a while. Some are just starting, and many are still developing their technologies.
The technologies that are being shipped presently are:
Some other companies involved in development of Next Generation Sequencing technologies are:
CLC bio strive to support the latest technological developments, including the very interesting developments within Next Generation Sequencing (NGS).
For a while we have been working actively with development of solutions for supporting these technologies - behind the scene. Recently we started to make some of the initiatives public, among others our research collaboration with 5 Danish research institutions on developing a Next Generation Sequencing software platform. Click here to read more…
This project - as well as other projects that we are involved in - will enable us to develop truly unique algorithms and software tools for analysis of Next Generation Sequencing data. In the coming months and years, we will develop a wide range of new tools suited for Next Generation Sequencing, some of which are:
- Reference assembly of genomes
- De novo assembly of genomes
- SNP detection
- Digital Gene Expression
- Metagenomics
- Clustering and assembly of EST and cDNA sequences
- A large amounts of genomics and transcriptomics downstream analyses
- Workflow support
In the first phase of our development, we focus on 454, Solexa, and SOLiD data, but soon Helicos data and others will be included. Collaboration with the instrument vendors is a natural part of our development process.
Given the enormous amounts of data, our skills and experience within High Performance Computing (HPC) is of high value, and our Next Generation Sequencing solutions will be fully integrated with existing and upcoming HPC-solutions.
Our first Next Generation Sequencing solution will be CLC Genomics Workbench, including assembly of Next Generation Sequencing data and support for a number of downstream analyses and work-tasks.
Click here if you have questions about our upcoming Next Generation Sequencing solutions, or if you are interested in learning more about them.
Friday Helicos BioSciences announced that they have sold their first Helicos Genetic Analysis System. The system consists of the HeliScope Single Molecule Sequencer, the HeliScope Analysis Engine, and the HeliScope Sample Loader, all designed for production-level genetic analysis based on the company’s proprietary sequencing-by-synthesis approach called True Single Molecule Sequencing (tSMS).
For us bioinformaticians this means more challenges, as we may soon be looking at data sets that contain billions of reads rather than the millions that we are currently trying to tackle. Never a dull moment…
For long, talk has been going around about George Church’ involvement in the production of a new and “cheap” next generation sequencing platform. Now it is here. At the Danaher website they describe their entry to the NGS market as:
… a completely open platform, combining a high performance instrument at a very low price point, with freely downloadable, open-source software and protocols, low-cost, off-the-shelf reagents, and inexpensive flowcells. .. all aspects of the system are open and programmable, providing the flexibility to support a wide range of alternative sequencing methods.
