Next Generation Sequencing

NimbleGen are now offering their high-density oligonucleotide microarrays as a programmable genomic selection technology to allow targeted sequencing of genomic regions such as e.g. exons.

NGS technologies are based on random amplification of input DNA. This makes sample preparation easier but leaves the actual sequencing undirected. The idea of capture arrays is to insert a selection step prior to the actual sequencing. The array is programmed to capture only the genomic regions of interest and thus enable users to utilize the full capacity of the NGS machines in the sequencing of specific genomic regions of interest.

Image from the NimbleGen website, illustrating the array capture process.