Next Generation Sequencing

PolITiGenomics have posted some details about the upcoming update to the 454 system.

According to the blog, the next upgrade will be called Titanium and will have twice the number of cycles increasing  the average read length from 250 to around 400 bases. Furthermore, the new version will have smaller, more densely packed wells on the picotiter plate which will increases the number of DNA fragments sequenced per run. All together, 454 FLX Titanium runs will quintuple their data output from 100 Mb to about 500 Mb.

Obviously, the increased data amount will put even more strain on the downstream image- and sequence analyses pipelines.