Jul 23 2008

New white paper on our updated assembly algorithm

Tag: Development, TechnologyGoerlitz @ 2:40 pm Email This Post

We have just released a scientific white paper which confirms, that, in benchmarking tests, our new algorithm for assembly of Next Generation Sequencing data is indeed fast. Not only is our algorithm fast, but it also provides a better quality of the results, compared to other algorithms benchmarked in the white paper.

Assistant Professor at Rutgers University, Dr. Todd P. Michael, states,

The speed of CLC bio’s new algorithm for reference assembly of Next Generation Sequencing data raises the bar to a level currently unmatched by any competitor. When CLC bio continues this impressive rate of development, and eventually also handles SOLiD’s Color Space analysis in the same convincing manner, this could easily become a de facto tool for scientists working with Next Generation Sequencing analysis.

The white paper is free to download for everyone at www.clccell.com/ngs

You can read the entire press release by clicking here


Jul 02 2008

Comparative whole-genome sequencing of yeast

Tag: Researchrforsberg @ 7:51 am Email This Post

In a new paper out in PNAS, Michael Lynch and colleagues report their findings from a comparative whole-genome pyrosequencing of yeast genomes. A total of four haploid genomes were sequenced in the study using the 454 platform. Surprisingly, the researchers found that the number of large scale genome events (insertions, deletions, duplications etc) was comparable to the number of point mutations that occurred.

Sequencing was done with highly variable coverage along the genomes and this have caused the authors to hypothesize that the yeast clones are actually not truly haploid but seem to be entering a partly diploid stage where some chromosomes are diploid and some haploid.

GenomeWeb has an interview with the first author where he elaborates on this


Jul 01 2008

Finally, High Througput Sequencing put to good use

Tag: Researchrforsberg @ 8:50 am Email This Post

Today, a U.S. Department of Agriculture team, funded with more than $10 million from Mars Inc., announced that they will start sequencing the cocoa genome. The results are likely to help in the battle against cocoa plant diseases and, much more importantly, they could also lead to better-tasting chocolate.

A lot of people would probably also be thankful if the results could guide us towards a diet version with the same taste :-)

Update: IMB has posted a video promotion of this research project at YouTube.