Next Generation Sequencing

Here at CLC bio the developer team is really proud to have released the second major version of our Genomics Workbench.

A full list of the new functionalities is provided here.

Most importantly the release includes:

• Support for reference assembly against the human genome (i.e. reference sequences of any size)
• New and much faster algorithm for assembling short reads (less than 55 nucleotides)
• Significant performance improvements of reference assembly.
• True support for reference assembly of mixed data sets in one go. Sequencing data from different platforms (and both single and paired ends) can now be assembled together. Previously this could be accomplished by making separate assemblies and joining the contigs afterwards, but now this process is automated. 
• Reference sequences can be masked based on annotations. This could be used to e.g. mask off repeat regions or only include exons in the assembly. The reference sequences have to be annotated in order to use masking.
• Loads of SNP reporting improvements
• Improvement of the trim functionality
• Improvements of import functionality including support for Illuminas SCARF file format
• Great improvements in annotation handling of heavily annotated genomes.
• Some bugfixes.
• And lots more…