Jan 14 2010

Looking back on the first 5 years

Tag: Misc.Goerlitz @ 11:44 am

With a plan of revolutionizing the software for genetics and genomics, CLC bio was founded by brothers Bjarne and Thomas Knudsen on January 4th 2005. We first started out with a free program - what is today known as CLC Sequence Viewer - which was launched in the Summer of ‘05. Later that year we launched our first commercial product and soon after more followed. All along we found ourselves having considerable success with our formula of delivering advanced bioinformatics algorithms wrapped in a user-friendly graphical user-interface.

The very first project plan

Right from the start we had a global mindset, wanting all scientists working with bioinformatics and molecular biology to have our applications installed on their computers. We focused heavily on driving potential users to download our software directly from our website and had considerable success in doing that. One year after the first release we reached 100 000 downloads, 400 000 two years later and in 2008 we crossed the magic barrier of 1 million downloads.

But it wasn’t just good decisions all the way

The very first project plan

Our venture in to FPGA technology with our Bioinformatics Cube was very interesting and we made some nice implementations of known algorithms, but basically two things weren’t as we originally expected. The market was smaller than anticipated and we were simply too good accelerating the same algorithms with SIMD technology on existing computer hardware. That in essence has taken over for most of our FPGA development. But the Cube surely works well in itself and looks nice - and people still talk about it when we’re at conferences and exhibitions, so something apparently was done right.

Some marketing guy *cough* also bought heaps of nicely designed cardboard boxes for the software, in anticipation that people would like to have their avant-garde software shipped physically after purchase. How wrong! All the boxes, minus a couple, are still in the basement and would at some point make a very nice bonfire in the parking lot…

Oh, and there was the very first board meeting which was in crisis mode, shortly after starting the company: The company was named “Geniematics” back then, but an American company who had a product with a similar name kindly sent a letter asking us to use another name for our company. A couple of months in naming despair ensued before settling on the acronym “CLC bio” which to this day remains a secret. Contrary to popular belief it’s not “cake loving company” although we do like cake. A lot.

The very first project plan

Recent years

In 2007 we changed strategy, focusing primarily on Next Generation Sequencing data analysis. That was probably the single most important decision in the company’s history and has lead to the market position we have today, with some very ample solutions for analyzing high-throughput sequencing data from all the major NGS platforms. A fact also stressed when our enterprise platform, CLC Genomics Server, won the Best of Show award at the Bio-IT World Conference and Expo in 2009.

Here five years later, after revealing some very positive fiscal numbers from 2009 last week, we can honestly say that the future has never looked brighter for CLC bio!

CLC 2010


Jan 13 2010

Another Stop on the Road to the $1,000 Genome

Tag: TechnologyGoerlitz @ 11:47 am

Yesterday, Dan Vorhaus, wrote an excellent comment on Illumina’s new instrument announced at J.P. Morgan’s Healthcare Conference in San Francisco.

According toMatthew Herper of Forbes.com, Illumina’s new machine “will decode a person’s DNA in one week using $10,000 worth of materials – five times cheaper than any other competing gadget on the market

Oh - and BGI also announced that they bought a whopping 128 of these machines, confirming their lead as one of the global leaders in sequencing.


Dec 03 2009

How does “BIOINFORMATICS” sound?

Tag: Misc.Goerlitz @ 1:19 pm

As a little fun project, we have developed our take on how the word “BIOINFORMATICS” sound… take a listen!

Creative Commons License
Bioinformatics by CLC bio is licensed under a Creative Commons Attribution-Noncommercial-No Derivative Works 3.0 United States License.


Nov 17 2009

3rd Gen Sequencing company PacBio reveals commercial specs

Tag: TechnologyGoerlitz @ 11:14 pm

In today’s edition of In Sequence, editor Julia Karow, revealed a number of performance specifications for PacBio’s first commercial single-molecule real-time DNA sequencer, due to be released during the second half of 2010.

PacBio CEO, Hugh Martin, states:
Our pricing strategy, at this time, is that we are going to probably fix a $100 per-run cost. Over time, that price is going to remain the same, but the amount of sequence that you will get for that $100 will go up tremendously. The minimum run time is between 10 and 15 minutes, which users can adjust, depending on whether they want to maximize their throughput or read length. An entire experiment, from the time that you start sample prep to when you have your data, can be completed in less than 12 hours.

Click to read the entire article at In Sequence (requires subscription)


Nov 04 2009

New benchmarks of our upcoming de novo assembler

Tag: Development, Technology, UpdatesGoerlitz @ 9:27 am

We have had our upcoming de novo assembly algorithm in internal Alpha for some time now, and have just released an updated technical note with benchmarks from the Alpha 2 version, which is the version we’re currently running.

Impressive benchmarks
These new benchmarks are quite impressive: De novo assembly of a data set with 38 fold coverage of the human genome, completed in only 7 hours on a single computer, while also improving the overall quality!

Click to download the PDF-file with benchmarks on the Alpha 2 version of our upcoming de novo assembly algorithm

Interested in trying this de novo assembler yourself?
Hopefully we can have the beta version out for public testing before Christmas - stay tuned! If you’re interested in more information, you can sign up here and get an invitation, once it’s released: Click to sign up for a beta trial of our de novo assembler


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